Pagoclone | Analytical Grade Cyclopyrrolone Derivative for Research

Product Overview

SARMs research compounds, is a synthetic non-benzodiazepine ligand belonging to the cyclopyrrolone class, structurally related to contemporary agents such as zopiclone and suriclone. According to the Pagoclone Wiki, its chemical architecture allows it to bind to the benzodiazepine site of the $\gamma$ -aminobutyric acid type A ( $\text{GABA}_\text{A}$ ) receptor complex. Unlike classical full agonists, Pagoclone acts as a high-affinity partial agonist, exhibiting pronounced functional selectivity for specific receptor configurations. This makes Pagoclone a primary subject of interest for investigators examining the separation of anxiolytic pathways from sedative-hypnotic side effects and studying novel modulators of inhibitory neurotransmitter systems.

Researchers can source high-purity reagents and reference materials directly through Chem S Supply.

Technical Specifications

Parameter	Specification
Chemical Name	2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-2,3-dihydro-1H-isoindol-1-one
Class	Cyclopyrrolone / Non-Benzodiazepine $\text{GABA}_\text{A}$ Ligand
Concentration	Available as highly purified crystalline powder calibrated for quantitative analytical validation
Format	Analytical grade solid optimized for high chemical stability, precise mass measurement, and solution preparation
Purity	$\ge 98\%$ verified via NMR spectroscopy and LC-MS analysis

Primary Research Applications

Pagoclone is supplied exclusively for established scientific frameworks, including:

$\text{GABA}_\text{A}$ Subtype Selectivity Mapping: In-vitro evaluation of the compound’s partial agonism and binding kinetics at $\alpha_1$ , $\alpha_2$ , $\alpha_3$ , and $\alpha_5$ subunit-containing $\text{GABA}_\text{A}$ receptors, specifically profiling its low-intrinsic efficacy at the $\alpha_1$ subtype.
Structural-Activity Relationships (SAR): Investigating how the isoindolone and naphthyridine core elements of cyclopyrrolones interact with the benzodiazepine binding pocket compared to classical 1,4-benzodiazepines.
Metabolic Pathway Clarification: Mapping the enzymatic reduction and oxidation profiles of non-benzodiazepine compounds in hepatic and cellular assay models.

Safety, Storage, and Regulatory Compliance

Strict adherence to standard laboratory safety protocols ( $GLP$ ) is required during handling SARMs research compounds

⚠️ Laboratory Notice & Intended Use

This compound is synthesized and distributed strictly for in-vitro laboratory research and analytical applications. It is explicitly not intended for human or veterinary diagnostic, therapeutic, or clinical consumption.

Documentation: All shipments are accompanied by a comprehensive Safety Data Sheet (SDS) detailing toxicological data, reactivity profiles, and safe handling procedures.
Storage Conditions: To maintain chemical integrity and prevent degradation, store the compound in a cool, dark, and desiccated environment (ideally between $2^\circ\text{C}$ and $8^\circ\text{C}$ or below for long-term reference stability).

Institutional Procurement & Logistics

Inventory Selection: Available in scalable quantities calibrated for varied institutional budget allocations and project scopes.
Secure Transactions: Encrypted checkout protocols ensure the absolute protection of institutional procurement and proprietary data.
Logistics: Shipped in secure, stable packaging to preserve chemical integrity during transit, complete with tracking and automated delivery confirmation.

Support and Technical Consultation

For volume inquiries, bulk pricing schedules, or to request batch-specific Certificates of Analysis (CoA), please submit a formal inquiry to our technical support desk via Chem S Supply.

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Cyclopyrrolon

Pagoclone Pellets – 10mg